Question

L- DOPA, a treatment given to Parkinsons patients, can produce dyskinesia a negative side effect involving tics or uncontrollable movement patterns, cause

1) L-DOPA activates the indirect pathway of the basal Ganglia.

2) L-DOPA is converted into dopamine in the substantia Nigra. Substancia Nigra neurons then project down the spinal cord and excite alpha motor neuron pools.

3)L-DOPA crosses the low brain barrier (BBB) and travels to the primary motor cortex activating random muscle groups.

4) L-DOPA is taken up by the rain and converted into dopamine, unintentionally reinforcing arbitrary motor behaviors coinciding with self administration of the drug.

Answer 1

3- L-DOPA crosses the low brain barrier (BBB) and travels to the primary motor cortex activating random muscle groups.