Question

Subject 504V56 is a research animal (dog), she was diagnosed with Pyruvate kinase Deficiency (PKD). PKD is a genetic metabolic disease that causes pyruvate kinase to be absent or greatly reduced. Pyruvate kinase is the enzyme in the 10th and final step of glycolysis. This means that pyruvate is not created To ensure that she can continue producing ATP, her diet should be fortified with which of the following macromolecule types? 1. Carbohydrates like glucose 2. Lipids like lard and oil 3. Proteins like meat 4. Vitamin B2 5.phosphorus Select one of the above and explain why in 1-2 sentences:

Answer 1

Option 2 is correct. Lipids with lard and oil. Lipids breakdown produces Acetyl CoA which Carry the citric acid cycle. Because due to low pyruvate level, acetyl CoA cannot be produced from link reaction. So lipids provide acetyl CoA and this carry the further processes and can continue producing ATP.