Question

4 Questions. I'll rate if they are correct!
QUESTION 1 What is the overall yield of Product D in the following step-wise synthesis? The % yield of each step is noted at the bottom of each arrow. Step 1 Step 2 Step 3 А B D 90% 80% 70% 50% O 60% O 70% 80% QUESTION 2 What is the overall yield of Product E in the following convergent synthesis? The % yield of each step is noted at the bottom of each arrow. Step 1 A B 90% Step 3 →E 70% Step 2 с D 90% 31% 63% OOOO O 70% 90%

Answer 1

Solution:- Question-1:- 50% The overall yield of a linear scheme having n step is given by following formula. Multiply all percentage yields in all steps Over all yield 100n-1 Over all yield 90 x 70 x 80 1003-1 504000 1002 504000 10000 = 50.40% 50% Question-2:- 63% If you have two linear way then use one way to calculate the overall yield. Over all yield Multiply all percentage yields in all steps 100n-1 Over all yield 90 x 70 1002-1 6300 1001 6300 100 63% Question-3:- Sigmatropic reaction [3,3)-sigmtropic reaction 2 Question-4:- Cheletropic reaction COQEt COOEt Me Me NEN +N2 Me Me COOEt COOEt