Question

Question 2 Imagine you are a scientist who intends to cure sickle cell disease. Which approach would be best suited to this goal? a. Dietary supplements to make up for an enzyme deficiency b. Modification of ribosomes to enhance translation c. Exposure to X-rays to induce a new mutation d. Dietary supplements to make up for an amino acid deficiency e. Editing the gene for a polypeptide component of hemoglobin

Answer 1

Q2. In my opinion option (e) is the right answer: Editing the gene for a polypeptide component of haemoglobin.

Let's understand this: Sickle cell anaemia is a genetic disorder which is caused to mutation in haemoglobin gene. This causes faulty haemoglobin which precipitates and causes the changes in shape of the RBC (Sickle). The RBC is not viable and is destroyed in circulation as it does not have proper flexibility to pass through narrow blood vessels.

So, Editing the gene will definitely help to solve this problem.

Option B is not possible: The problem starts early during mRNA formation. Other options like dietary supplements will provide temporary or no help at all.

Q7. The correct answer is option D : Binding a protein releasing factor, causing hydrolysis of the bond between polypeptide chain and tRNA.

STOP codons are codons that halts protein synthesis since the tRNA does not have an anticodon for that resulting in stoppage and release of proteins.

Q.11 The concept of CENTRAL DOGMA states that the flow of information is unidirectional from DNA to mRNA and then to proteins.

OPTION D is the right answer.

Option A: Protein does not encode any information (forget about Prions): Wrong Answer

Option B: The information of DNA is not directly changed to proteins as original information from DNA, a cell cannot transcribe. It needs an intermediate (mRNA)

Option C: Similar explanation to option A.

Option E: This is also not possible