Question

You want to create an anti-cancer drug that destabilizes microtubules, hoping to prevent cell division in the cancer cell line that you are studying. Which of the following drugs would enhance microtubule shrinkage and, therefore, utilize this mechanism of action? Answers A-D A a drug that inhibits GTP hydrolysis by the B-subunit in the GTP cap O B a drug that increases the ability of a tubulin dimer to bind to y-tubulin of the centrosome с a drug that increases the affinity of GDP-bound tubulin molecules for other tubulin molecules, increasing the stability of the polymer o D a drug that stimulates hydrolysis of the GTP carried by the B-subunit of the tubulin dimer O

Answer 1

The correct answer is

A drug that inhibits GTP hydrolysis by B-subunit in the GTP cap would enhance microtubule shrinkage.