Adding acetophenone slowly to a cold solution of LDA produces the enolate of acetophenone; but adding LDA slowly to a cold solution of acetophenone produces a condensation product. Draw the aldol product that results from the slow addition of LDA to acetophenone.
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Adding acetophenone slowly to a cold solution of LDA produces the enolate of acetophenone; but adding...
Adding acetophenone slowly to a cold solution of LDA produces the enolate of acetophenone, but adding LDA slowly to a cold solution of acetophenone produces a condensation product. Draw the resonant structures that result from adding acetophenone to cold solution of LDA.
2) Consider the mixed aldol condensation reaction of 1-(1-methyleyclopentyl ethanone (shown in question 1) and propiophenone (shown below). Two major MIXED aldol condensation poducts arise from this reaction (shown below, labeled A and B) If you wish to form product B, to which starting carbonyl would you add a strong base such as LDA in order to form the enolate? Which carbonyl would you then add slowly to the enolate of the first carbony!
la) Consider the mixed aldol condensation reaction of 1-methylcyclopentane-1-carbaldehyde (shown below) and 3,3-dimethyl-2-butanone (shown below) in the presence of sodium hydroxide Provide the expected major MIXED aldol condensation product for this reaction (can exist as E or Z isomer so you can draw either) b) Would you have to heat the reaction mixture in order for the reaction to form the aldol condensation product? Why or wh y not? 2) Consider the mixed aldol condensation reaction of 3,3-dimethyl-2-butanone (shown in...
OH LDA - в THF, -78 °C (a) There are four possible sites of deprotonation on compound A. Re-draw compound A, indicating each of these sites with an asterisk. (2] (b) Under these conditions, deprotonation with LDA gives the kinetic lithium enolate B. Give a curly arrow mechanism for the formation of B. [2] (c) Draw a curly arrow mechanism for the intramolecular aldol reaction of enolate B to give product C. [3] (d) Draw a curly arrow mechanism for...
In Organic Chem II from the Aldol Condensation lab (using 3-nitrobenzaldehyde, acetophenone, ethanol, sodium hydroxide, methanol and final product 3-nitrochalcone) please help anser the following answer. Please write clear; many times it's hard to read response on Chegg-thank you. 1. There are two possible products of this aldol condensation. Draw the structure of both. 2. Explain why only one aldol product is formed in this reaction. Comment on both the reactivity of the starting materials as well as your experimental...
In today's experiment you will synthesize the a,ß-unsaturated ketone from 3- nitrobenzaldehyde and acetophenone via an aldol condensation. Once the aldol product forms, the reaction spontaneously dehydrates to the conjugated enone. This reaction fulfills some of the principles of green chemistry in that it has high atom economy, produces water as the only major byproduct, and uses ethanol as a non-toxic solvent. ON NaOH Etон Ph Which aldehyde will work better in this reaction as an electrophile: 4-cyanobenzaldehyde or 4-methoxybenzaldehyde?...
2-Methylcyclopentanone treated with lithium diisopropylamide (LDA) followed by addition of formaldehyde results in a crossed aldol reaction. OH (1) LDA (2) 4,0 Complete the mechanism for the reaction by adding missing curved arrows, atoms, bonds, charges and nonbonding electrons. introduced the aldehyde 0: с + NH(Pr)2 Но сна Сн, ен, GH енен, Water added in workup step. өн H3C НЭС final product NOY
Write structures for the carbonyl electrophile and enolate nucleophile that react to give the aldol below. • You do not have to consider stereochemistry • Draw the enolate nucleophile in its carbanion form. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right comer. • Separate multiple reactants using the + sign from the drop-down menu. 2reg 2req - 0000 ats zreg pts2reg Ulaw studies for the carbonyl electrophile and enolate nucleophile that...
Aldol Condensation: 1) What is the purpose of using NaOH solution in this Aldol condensation? 2) Why acetic acid is used to wash the solid on the fiter? 3) Draw the structure of the product from the reaction: NaOH H +Acetone in ethanol
1. The reaction web includes most of the reactions of enolates we have studied. The products of these reactions can be treated with other reagents to generate new functionality - think synthesis! Make up your own examples - e.g. What if you treated compound D with CH,MgBr? In the table, summarize the types of products produced from these reactions. CH3 MgBr acid quench acid quench NaOH, H2O EIO OEt acid quench acid quench acid quench D LIAIHA acid quench acid...