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B С Question 24 Which of the following is NOT an allosteric effector of hemoglobin? oxygen 2,3-bisphosphoglycerate O all the
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24- option C

  • ie, both OXYGEN and 2,3-bisphosphoglycerate act as an allosteric effector of haemoglobin.
  • ALLOSTERIC EFFECTORS are a molecule that binds to an enzyme and causes allosteric effects.
  • >Positive allosteric effects involve "activation" of the enzyme - increasing its activity. >Negative allosteric effects involve "inhibition" of the enzyme - decreasing its activity.
  • Oxygen release from hemoglobin (Hb) is regulated by the allosteric effector 2,3-bisphosphoglycerate.
  • Oxygen itself act as both allosteric effector and substrate.
  • Binding of oxygen enhances the attraction between substrate molecules and other binding sites leads to Positive allosteric modulation.
  • Therefore, both OXYGEN and 2,3-bisphosphoglycerate act as an allosteric effector of haemoglobin.
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