Question

Paracentric inversions are genome features that effectively prevent recombination. Loci A and B are 5x10⁶ base pairs apart but are part of the same inversion (i.e. they do not recombine). Locus C lies outside the inversion and is 6x10⁶ base pairs from A and 1x10⁶ base pairs from B. Assume that in the human genome 1x10⁶ base pairs correspond approximately to 1 m.u. when loci can freely recombine. "Draw" a physical and a linkage map for the 3 loci listing map distances in base pairs and m.u. respectively. Provide both maps in the following format (distances are not correct and are just given as an example) :

Physical: A>>10bp>>B>>10bp>>C

Genetics: A>>5m.u.>>B>>5m.u.>>C

Answer 1

Answer:

be = 5m.u Distance between Locus A and B = 5x100 Distance between Locus B and C = 1x 18 bp = imu Distance between Locus A and C= 6x10 bp=6 m. Since 1x 10 bp=1mu Physical map :- 은 8x106 bp 1 5x10 bp 1x10 lp Physical : A >> 5x10bp>B>> Ixcöbp> 70 6m.u A Linkage map :- mu 5m.u Genetics :- A>>5 mu77B771 m.u>70

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