Question 21
Answer: Fructose-1,6-bisphosphatase
The conversion of Fructose-1,6-bisphosphate to Fructose-6-phosphate in gluconeogenesis is catalyzed by the enzyme Fructose-1,6-bisphosphatase while the opposite reaction occuring in glycolysis is calalyzed by Phosphofructokinase. The Fructose-1,6-bisphosphatase enzyme is absent in glycolysis.
All other enzymes are present in both glycolysis and gluconeogenesis and catalyze reactions in opposite direction.
Question
Answer: Gluconeogenesis is simply the reverse of glycolysis
Gluconeogenesis is not exactly the reverse of glycolysis. Three steps differ in them and use different enzymes. The conversion of Phosphoenolpyruvate to Pyruvate is catalyzed by Pyruvate kinase in glycolysis while the opposite reaction in gluconeogenesis is catalyzed by two enzymes (pyruvate carboxylase and pyruvate carboxykinase) and involves Oxaloacetate as an intermediate. Similarly, the conversion of Fructose-1,6-bisphosphate to Fructose-6-phosphate is catalyzed by Fructose-1,6-bisphosphatase while the opposite reaction in glycolysis is catalyzed by Phosphofructokinase. Also, the conversion of glucose to glucose-6-phosphate is catalyzed by Hexokinase (or Glucokinase) in Glycolysis while the opposite reaction in gluconeogenesis is catalyzed by Glucose-6-phosphatase.
Glycolysis breaks down a large glucose molecule into smaller pyruvate molecules and is catabolic, Gluconeogeneis does the opposite and is thus anabolic.
The four enzymatic reactions mentioned above are unique to Gluconeogenesis.
Gluconeogenesis syntheisizes glucose from pyruvate.
Question 25
Answer: Glucose-6-phosphate
Since the conversion of glucose-6-phosphate to glucose is catalyzed by Glucose-6-phosphatase, the absence of this enzyme will cause the accumulation of the substrate which is glucose-6-phosphate.
No other option given in question is the substrate of the enzyme glucose-6-phosphatase.
Question 26
Answer: It decreases glycolytic activity
The enzyme Hexokinase involved in glycolysis is allosterically regulated by the glucose-6-phosphate which is the product formed by the enzyme. Higher the concentration of glucose-6-phosphate, lower becomes the activity of the Hexokinase enzyme due to a negative feedback mechanism. Thus, glycolysis will be slowered down by glucose-6-phosphate accumulation.
Since the feedback is negative, it cannot increase the glycolytic activity.
Also, it downregulates the Hexokinase activity but cannot completely stop it. Thus, cannot completely stop glycolysis.
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i need right answers for these four questions please as I am stuck in it. thank...
32. The gluconeogenic precursor thereby generated is alpha-ketoglutarate. The pathway e pathway by which it can be converted to glucose is: Enzyme alpha-ketoglutarate dehydrogenase succinyl-CoA synthetase succinate dehydrogenase Product succinate L-malate malate dehydrogenase phosphoenolpyruvate 3-phosphoglycerate glyceraldehyde-3-phosphate 0 enolase phosphoglycerate mutase phosphoglycerate kinase triose phosphate isomerase fructose-1,6-bisphosphate ctose bisphosphatase glucose-6-phosphate glucose-6-phosphatase
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Match the enzyme to the substrate --> product reaction to which it catalyzes. O Hold and drag to reorder Phosphoglycerate Mutase Glucose --> Glucose 6-phosphate Phosphohexose Isomerase 1-3- Bisphosphoglycerat e--> 3- Phosphoglycerate Hexokinase Fuctose 1-6- bisphophate --> Glyceraldehyde 3- phosphate + Dihydroxyacetone phosphate Phosphoglycerate Kinase Oxaloacetate --> Phosphoenolpyruva te Aldolase Mannose 6- phosphate -> Fructose 6- phosphate Pyruvate kinase Dihydroxyacetone phosphate -> Glyceraldehyde 3- phosphate Enolase Glyceraldehyde 3- phosp Bisph Submit Glyceraldehyde 3- phosphate Enolase Glyceraldehyde 3- phosphate -> 1-3-...
I am confused with this glucose structure, Can you answer the question asked on the right side of the page, please? Glucose Hexokinase ATP Glucose 6-phosphate Phosphoglucose isomerase Fructose 6-phosphate Phosphofructo- ATP kinase-1 ADP Dihydroxyacetone phosphate Fructose 1,6-bisphosphate Aldolase Triose 5 phosphate Glyceraldehyde isomerase 3-phosphate (2 molecules ) Glyceraldehyde 2 NAD+ +2P, 3-phosphate 2 NADH + 2H dehydrogenase I 1,3-Bisphosphoglycerate (2 molecules) 7 Phosphoglycerate 2ADP kinase 2 ATP 3-Phosphoglycerate (2 molecules) Phosphoglycero- mutase 2-Phosphoglycerate (2 molecules) Enolase. > 2H2O Phosphoenolpyruvate...
Why are these reactions for gluconeogenesis exergonic? I get that Glucose 6-phosphate -> glucose and fructose 1,6-biphosphate -> fructose 6 phosphate release Pi, but doesn't the formation of formation of oxaloacetate and phosphoenolpyruvate require energy ( ATP and GTP) ruvate. CH,OH CHOPO; HO он glucose 6- phosphatase HO OH OH 94 Он glucose 6-phosphate glucose glycolysao OPOH COCHZOPO HO O HO OH fructose 1,6- bisphosphatase ,POH COCH,OH HO он OH fructose 6-phosphate OH fructose 1,6-bisphosphate HCO; + ATP ADP +...
Please answer the question. Please write neatly and also make sure you answer is correct! Thank you! If you do not know the answer to a part, please don’t answer it! I will rate good! Also please fill in the blank followed by the letter choice. 7. (8 pts) Complete the following statements about glycolysis using terms from the list below. Four of these will not be used. 3-phosphoglycerate aldolase dihydroxyacetone phosphate enolase fructose 1,6-bisphosphate glyceraldehyde 3-phosphate lactate oxidative pyruvate...
Glycolysis activity 1: Metabolic pathway puzzle Try to complete the activity without using the textbook. 1. Slides 4 and 5 show the 10 reactions for glycolysis, but some of the molecules are missing. Draw the missing molecules in the proper place (on the handout). The missing molecules are shown on the next slide, you have to use the clues on the handout and your organic chemistry knowledge to figure out where each molecule belongs. 3. In the red dotted boxes...
2) if a single glucose molecule was completely catabolized to 2 pyruvate, then the liver built the 2 pyruvate back to glucose, how much free energt would be lost? 4) at which glycolysis metabolite does glycogen synthesis amd the pentose phosphate pathway branch off from? MIBROS JUJILOR DUE 3/13 at the beginning of class CHOH ресто points) OPOCH HO PHY OH OR equal ts3 > Loc Energy 50 Investmen when Phase n ] ohuoc but at Glucose 1)(6) Fill in...
Please choose the BEST ANSWER. No cell phones, web or cameras, please. 1. Each of the following enzymes functions in both glycolysis and gluconeogenesis except: A) 3-phosphoglycerate kinase B) aldolase C) enolase D) phosphofructokinase-1 E) phosphohexose isomerase During strenuous exercise, the NADH formed in the glyceraldehyde 3-phosphate dehydrogenase reaction in skeletal muscle must be reoxidized to NAD if glycolysis is to continue. The most important reaction involved in this reoxidation of NADH is: 2. A) dihydroxyacetone phosphate> glycerol 3-phosphate B)...
Need help with this. I need to match the text box with the following hexokinase,aldolase,phosphofructokinase,enolase,aconitase,furmarase. Thanks 10 pts Question 22 These enzymes are involved in Glycolysis and the Citric Acid cycle. Match the term with the correct function. Only one function is listed for each enzyme. Hexokinase [Choose Choose l Converts Citrate to isocitrate in 2 steps Succinate Dehydrogenase Aldolase Makes 2 three carbon molecules from Fructose 1.6 biphosphate Phosphorylates Fructose 6-phosphate in the presence of ATP Form Glucose 6....