Question

2) if a single glucose molecule was completely catabolized to 2 pyruvate, then the liver built the 2 pyruvate back to glucose, how much free energt would be lost?

4) at which glycolysis metabolite does glycogen synthesis amd the pentose phosphate pathway branch off from?

MIBROS JUJILOR DUE 3/13 at the beginning of class CHOH ресто points) OPOCH HO PHY OH OR equal ts3 > Loc Energy 50 Investmen when Phase n ] ohuoc but at Glucose 1)(6) Fill in all 6 blanks, whether they are ATP KH reactant/product names, enzyme names, or structures. When drawing structures, all Glucose-6-phosphate atoms must be shown, except for carbon in rings. phosphoglucose Isomerase 2)(1) If a single glucose molecule was completely Fructose co-phosphard -20, POCHY SHOH catabolized to 2 pyruvate, then N ou the liver built the 2 pyruvate ATP 3 phosphofructokinase Hb back to glucose, how much free ADP energy would be lost? - O,POCH, A CHOPOS Fructose-1,6-bisphosphate KWH Answer: 4 aldolase HO # 3)/3) Gluconeogenesis shares several enzymes with glycolysis. Which glycolysis enzymes does it not share? Glyceraldehyde- + Dihydroxyacetone CHOPO 3-phosphate phosphate ---OH CHOPO CHOH Answer(s): Pyruvate kinase Tclose Phosphate lo-Phosphofructokinase isomerase 2 P + 2 NAD glyceraldehyde-3- 6 phosphate ne ko kinase 2 NADH + 2H+1 dehydrogenase OPOS 2 1,3-Bisphosphoglycerate -OH 4){1) At which glycolysis CHOPO 2 ADP phosphoglycerate metabolite does glycogen synthesis and the pentose 2 ATP 00 phosphate pathway branch off 2 23- Phosphoglycerate from? H--OH CH_OPO phosphoglycerate Answer: mutase 1, and 60 Based mutas Energy Payoff Phase 2 2-Phosphoglycerate --OPO CH OH 2 H2O endiase e-okog 2 Phosphocnolpyruvate 2 ADP 10 pyruvate kinase 2 ATP 2 Pyruvate o СН 3

Answer 1

2) If the liver converts Pyruvate to Glucose then the loss in free energy will be 4ATP molecules.

For the Glucose to get converted to Pyruvate a net gain of 2ATP molecules is achieved, but for the reverse reaction i.e., from pyruvate to Glucose a net loss of 4ATP molecules occurs because for the conversion of 2 pyruvate molecules to 2 phosphoenol pyruvate molecules in the liver a total of 2 GTP and 2 ATP are required and also for the conversion of 2 molecules of 3 Phosphoglycerate to 2 molecules of 1,3-Bis phosphoglycerate, 2 ATP molecules are required and hence a net loss of 4 ATP molecules is taking place in the process of gluconeogenesis.

4) At glucose-6-phosphate metabolite, the glycogen synthesis and the pentose phosphate pathway branches off from glycolysis.