Question

28. Which is incorrect descriptions of the genetic event initiated by the HIV reverse transcriptase (RT) upon the HIV infection?

Select one:

a. RT catalyzes initial synthesis of ssDNA using viral genomic RNA as the template.

b. The first RNA template is degraded after ssDNA synthesis.

c. The whole process is completed after synthesis of dsDNA.

d. tRNAs are adopted as the first primers.

e. None of these

Answer 1

None of the given steps are incorrect. So option E is correct.

The HIV reverse transcriptase uses tRNA as primer and sunthesises a single stranded DNA using viral RNA as template. The template which remains attached to ssDNA is then degraded selectively by an endonuclease followed by conversion of ssDNA into dsDNA by DNA polymerase.