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Prepare any THREE of the following molecules, incorporating either an acetoacetic ester synthesis or a malonic...
Prepare any THREE of the following molecules, incorporating either an acetoacetic ester synthesis or a malonic ester synthesis in each synthesis. Show the reagents for each step and the product of each step. Do not draw any mechanisms. CO2Me H2N A B C D
6. Using either malonic ester synthesis or acetoacetic ester synthesis, outline a reaction scheme in each case to show how you will synthesize compounds A and B below. [Show all steps with structure of all intermediates and necessary reagents). A. 3-butyl-2-tetradecanone B. 2-propylpentadecanoic acid
Design a synthesis(no mechanism) for (Hint: use either a malonic ester or acetoacetic ester synthesis)
The Malonic Acid synthesis is similar to the Acetoacetic Ester synthesis It uses diethyl malonate as the main starting material Draw the structure of diethyl malonate (malonic ester) Diethyl malonate can be hydrolyzed back to malonic acid and if heat is applied after the hydrolysis, will decarboxylate. Draw the mechanism for this transformation starting with malonic acid. Indicate the new C-C bonds in each molecule and then provide the organohalides which were used to synthesize each compound using the malonic...
28- The following molecules can be formed by either: Michael Reaction; Enamine Acylation; Acetoacetic Ester Synthesis; Michael Addition; Malonic Ester Synthesis; Robinson Annulation; Aldol Condensation; Claisen Condensation; Intramolecular Aldol Condensation; Dieckmann Condensation or a Combination of two of the above listed reaction. In each case write the proper of the reaction on the line and dissect the product into appropriate starting material. In some cases there might only be one starting material. You may use any one of the above...
alon 4) Design a synthetic route that would form the following ketone using Acetoacetic Ester or Malonic Ester Synthesis. You can utilize any aldehyde, ketone, ester alkyl halide, acid, base, and any additional inorganic reagent or solvent needed. Remember to be specific with your choice of reagents and cond itions. Draw out each synthetic step with the reagent(s) needed for performing that step. (20 Pts) Sorry this ir all Over the plau... ( tricd to draN Prth но
The acetoacetic ester synthesis is a carbonyl alkylation reaction. It is used to prepare methyl ketones from primary alkyl halides, lengthening the carbon chain by three atoms. Thus, the product can be visualized as being a "substituted acetone." The reaction consists of three steps: generation of the enolate anion followed by S2 reaction with a primary alkyl halide, ester hydrolysis under acid conditions, and decarboxylation. 1. NaOEt 2. H2O* 3. heat Br + - H₃C + CO2 + ETOH Hc...
18 Question (3 points) Draw the three requested missing structures for this acetoacetic ester synthesis. Just draw the main organic product of each step-leave out any byproducts 1. NaOEt, EtOH 2. PhCH2Br 3. NaOEt, EtOH 4. CHal 5. NaOH, H2O 6. H30", heat 1st attempt Part 1 (1 point) al See Periodic Table See Hint Draw the product after Step 2:
Design a multi-step synthesis for each of the following target molecules from the indicated starting material. Show the reagents needed for each step and the product of each step. Do not show any mechanisms. Draw the structures of the diene and the dienophile that reacted to form the Diels-Alder product shown. Provide the missing reagents in this multistep synthesis.
owing compounds are "potential' targets for either the malonic ester or the aceto acetic ester synthesis? Circle them. For each of these, draw the structure(s) of the alkylating agents and structure(s) of the alkylating agents and indicate if the compound could be made efficiently by this method. OH