Question 5 1 pts Which of the following statements regarding the construction of V-region sequences is...
Question 5 1 pts Which of the following statements regarding the construction of V-region sequences is correct? (Select all that apply.) Heavy-chain V regions result from two somatic recombinations of V, D, and J segments; the first joins V to D, and the second joins VD to J. Light-chain V regions result from a single somatic recombination between V and J segments. Reversible alterations in the immunoglobulin genes occur during the development of B cells. Somatic recombination of heavy- and...
Which of the following statements is (are) true of a T cell that expresses two α chains (and thus two different T-cell receptors) as a result of ineffective allelic exclusion of the α chain during rearrangement? There will be two unique TCRs on the surface of this T cell. Engaging either of the T-cell receptors on MHC molecules of the thymic epithelium will result in positive selection. If either T-cell receptor binds strongly to self-peptide presented by self-MHC molecules, the...
This pathway to complement activation can be initiated by several different signals including the properdin/factor P activation pathway The classical pathway The alternative pathway Lectin pathway All of the above The mechanism that permits Ig to be synthesized in either a membrane-bound or secreted form is: Allelic exclusion Codominant expression The one-turn/two-turn joining rule Differential RNA processing Which of the following allows for recombination in the V(D)J coding regions? IL-2b TdT RAG-½ All of the above Generation of combinatorial diversity...
Case Study: As a member of a research team studying a tribe found in a remote region of New Guinea, you make the astonishing discovery that they have only two V genes for the L chain and three V genes for the H chain of immunoglobulins. Nevertheless, they seem healthy and able to resist the diversity of pathogenic organisms endemic to the area. Suggest how this might be accomplished 1. The DNA for an H chain in a B cell...
ANSWER ALL QUESTIONS FULLY AND CORRECTLY 5-1 T cells recognize antigen when the antigen a. forms a complex with membrane-bound MHC molecules on another host-derived cell b. is internalized by T cells via phagocytosis and subsequently binds to T-cell receptors in the endoplasmic reticulum c. is presented on the surface of a B cell on membrane-bound immunoglobulins d. forms a complex with membrane-bound MHC molecules on the T cell e. bears epitopes derived from proteins, carbohydrates, and lipids. 5-2 a....