Question

QUESTION 44 Describe the path a cell surface receptor will take when being synthesized (starting at the beginning of translation) to its expression on the plasma membrane - be sure to indicate the orientation of the receptor and any other processing that is undergoes. Describe the different possible fates of a receptor once it is internalized by receptor-mediated endocytosis. TTTT Paragraph Arial 3 (12) % Doa Τ' Τ.

Answer 1

Steps in the production of a membrane protein in eukaryotes:
1. Transcription of the gene in the nucleus to produce primary mRNA
2. Post-transcriptional modifications in the nucleus to produce the mature mRNA
3. Export of the mRNA out of the nucleus
4. Translation of the mRNA by ribosomes located on RER
5. The entry of the nascent peptide into the ER lumen
6. Post-translational modifications in the ER lumen
7. Export of the protein to the cis-face of the Golgi complex.
8. Post-translational modifications in the Golgi complex.
9. Packaging of the protein into vesicles
10. Trasport to the membrane and fusion