The regulators of G protein signalling (RGS) family of proteins are becoming increasingly important in the study of the mechanisms of disease development and represent potential targets for drug development. Which of the RGS protein subgroups acts by decreasing the ease with which the alpha subunit is activated rather than early signal termination?
Select one:
a. Rho GTPases
b. GDIs
c. GEFs
d. GAPs
Correct answer is option b - GDIs
Explanation: GDIs or Guanine nucleotide dissociation inhibitors acts when GAPs protein hydrolyze GTP (bound to Gα subunit) and replace bound GTP by GDP. GDIs stabilize the GDP bound state of Gα subunit and prevent replacement of GDP (which is already bound) by new GTP for activation of Gα subunit of G protein. So by this mechanism GDIs decrease the ease with which the Gα subunit is activated rather than early G protein mediated signal termination.
The regulators of G protein signalling (RGS) family of proteins are becoming increasingly important in the...
The regulators of G protein signalling (RGS) family of proteins are becoming increasingly important in the study of the mechanisms of disease development and represent potential targets for drug development. Which of the RGS protein subgroups acts through early termination of alpha subunit signalling rather than changing the ease with which the alpha subunit is activated? Select one: a. GAPs b. GEFs c. GDIs d. Rho GTPases