Question

3. Explain why every time we find a specific allele of a polymorphic locus in humans it is embedded within a haplotype that contains specific alleles of polymorphic loci that flank that locus. For example, three adjacent loci (Locus 31, Locus 32, and Locus 33) are all polymorphic and each locus has 6 different alleles found within the whole human population. Why do we tend to see specific combinations of alleles together at these three loci (e.g. the type 2 allele at Loc 31 is seen in a haplotype with type 4 allele at Loc32 and type 3 allele at Loc 33)? This haplotype example is shown below. Allele type2 Allele type4 Allele type 3 Example Haplotype: Locus 31 Locus 32 Locus 33 To be clear, there are other haplotypes in the human population with different alleles at these 3 loci.

Answer 1

Specific alleles of haplotypes in a polymorphic loci is determined by the combination of alleles present in its parental polymorphic loci. Haplotypes in single celled organism might have the same alelle combination from its only one parent and in sexually reproducing organism the combination of daughter alleles are different and it is based the parental allele combination. In three loci polynorphic site there are chances for many different combination that will have different alleles