Question

1. Gleevec is a drug that has transformed Leukemia treatment and cancer research. Gleevec is a form of therapy known as a TKI (tyrosine kinase inhibitor). Tyrosine kinase is an essential protein in cancer pathogenesis. Gleevec binds this protein and inactivates it. Hence it is able to cure treat certain cancers very effectively. Here is the chemical structure of Gleevec (not all hydrogens are shown): a) A dear family friend has contracted Leukemia. Gleevec has been proposed to be a successful treatment for this type of cancer. Unfortunately, your friend does not have insurance, and neither you or any of their friends or family are in a financial situation where they can pay for the treatment. You happen upon a reputable abaxseller and acquire some Gleevec in an intense bidding war for the amount of $5. However, you realize despite the seller's reputation you are hesitant to administer the drug to your friend because you doubt the authenticity of the product. analysis you can perform that will determine whether the drug you acquired is in fact, Gleevec? Include a brief description of what the expected results should be if it is Gleevec and what the results may be if it is a counterfeit drug? b) After an emotional office hours session with your gen chem prof, you successfully persuade them to call in a favor and conduct an elemental analysis on your suspect sample. You sent a 2.5 g sample of your compound. Unfortunately, a novice technician was on call at the time. They explain that they conducted a combustion analysis and give you the amount of water and carbon dioxide produced from the reaction. You immediately realize you do not have enough information to solve the problem. What was wrong with the experimental approach?

Answer 1

A)

To check that our product is Gleevac we perform NMR Spectroscopy technique, This technique provide the specific possition of proton rasonance under magnatic field . Now we can match the spectrum with the library data if peak possition of protons matched with standered Gleevac NMR Spectrum than we confirm that our product is Gleevac. If our spectrum, didnot match with library spectrum than we we conclude that it is a counterfeilt drug.

B)

Gleevac is made up of N, C, O, H elements. analyst provide the combustion analysis of material and give only ammount of water and carbon dioxide.  Water and carbon dioxide are gives only data of C, O, H elements. Data of rest N element is not provided by the analyst which is the mistake in analysis and provided information is ot sufficient to solve the problem.