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Outline the mechanism of the conversion of alpha k

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Answer #1

The mechanism of the conversion of alpha ketoglutarate to succinyl CoA catalyzed by alpha ketoglutarate dehydrogenase complex involves the following steps:

  1. Decarboxylation.
  2. Oxidation of 4-carbon group, reduction of lipoamide disulfide.
  3. Transacylation.
  4. Dihydrolipoyl dehydrogenase activity.
  5. Enzymatical FADH2 reoxydation by NAD+.
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