Question

What is the most acidic hydrogen in the following compound?

Question 19 Which is the most acidic hydrogen in the following compound? н н- H V O I He Н. -H IV -→H H ΟΙ O II O III O IV O V

Answer 1

The most acidic hydrogen in the compound is III.

Because it is adjacent to three carbonyl groups (C=O) which have strong electron withdrawing effect like -I effect and -R effects. Also after deprotonation of the proton III the conjugate base becomes very much stabilized by -R effects of the three adjacent carbonyl groups which makes the hydrogen III most acidic.

-I effect -s effect + * * الي -Ieffect H 8 ہم (most acidic proton. proton) - ہے E میئن نفرت H م نياز .. سنتی H اگه base is [ conjugate stabilised by - R effects of the adjacent carbonys three e , Youps (هو)