Inhibition of acetylcholine esterase at the neuromuscular junction would result in which of the following?
a) No change in muscle contraction frequency
b) Increased crossbridge formation
c) Decreased Na+ influx
d) Decreased Ca2+ release from the sarcoplasmic reticulum
Answer b. Increased cross bridge formation.
acetylcholine esterase breaks down acetylcholine present in the
synapse. Acetylcholine binds to ligand gated sodium channels and
causes depolarisation in the post synaptic membrane.
Inhibition of acetylcholinesterase will lead to increase in the
concentration of acetylcholine in the synapse.
Hence, the muscle will be continuously depolarised. This will lead
to formation of cross bridges between the myosin and actin
filament.
Inhibition of acetylcholine esterase at the neuromuscular junction would result in which of the following? a)...
Consider the neuromuscular junction between a pre-synaptic neuron and the diaphragm muscle. Acetylcholine is a neurotransmitter that is released from the presynaptic neuron to induce muscle contraction in the post-synaptic muscle cell. Which of the following would be an effect of tetrodotoxin? A. More acetylcholine in the synapse of the neuromuscular junction with the diaphragm B. Less acetylcholine in the synapse of the neuromuscular junction with the diaphragm
Put these steps in neuromuscular junction synaptic transmission and excitation-contraction coupling in chronological order. A. Ryanodine receptors open B. Voltage-gated Na+ channels open in the muscle cell membrane near the neuromuscular junction C. Tropomyosin rotates into the groove of the thin filament (out of the way of the myosin binding site) D. Depolarization of motoneuron axon terminal E. Ca2+ dissociates from troponin F. [Ca2+] rises in the muscle cell cytoplasm G. An EPSP occurs in the muscle cell H. Myosin...
Consider the neuromuscular junction between a pre-synaptic neuron and the muscle around the eye. Which of the following would be an effect of the Botox? A. More acetylcholine in the synapse of the neuromuscular junction B. Less acetylcholine in the synapse of the neuromuscular junction
Describe the effect of the botulinum toxin, which inhibits the release of acetylcholine at the neuromuscular junction. Would the poison curare, which competes for acetylcholine receptors (by attaching to the acetycholine receptors and preventing acetylcholine from binding) have similar effects? Explain.
All of the following are involved in neuromuscular transmission EXCEPT Select one: a. An increase in the permeability of the motor end plate membrane to Na+ and K+. b. An influx of Ca2+ into the motor axon terminal. c. Binding of acetylcholine to receptors on the motor end plate membrane. d. Depolarisation of the the muscle membrane adjacent to the motor end plate. e. Re-uptake of acetylcholine into the motor axon terminal.
Time Taken:0:07:07 Janki Patel: Attempt 1 Question 17 (1 point) What would be the result of a drug that blocked the binding of acetylcholine to acetylcholine receptors at the neuromuscular junction? sustained muscle contraction (tetanus) O increased sarcolemma depolarization inability of a muscle cell to break actin-myosin crossbridges muscle atrophy depolarization of T-tubules
1. What channels or carriers are NOT found at the axon to the axon terminal? Select one: a. Na+ leaky channels b. Cl- gated channels c. Na+ gated channels d. Na+-K+ ATPase e. None of the above 2. What is TRUE about action potential in the neuron? There may be more than one answer. Select one or more: a. At resting membrane potential (-70mV), the inactivation gate of the Na+ channel is closed while the activation gate is opened. b....
What would happen if the skeletal muscle voltage sensor failed to change from its activated state to its inactivated state following membrane depolarisation? A) the Ca2+ release channel would not activate B) released Ca2+ will not be enough to activate force production C) Ca2+ release from sarcoplasmic reticulum would be prolonged D) there would be no Ca2+ release E) the surface membrane would not repolarise
Botulinus toxin causes paralysis by binding to presynaptic sites at the neuromuscular junction and prevents release of acetylcholine from the vesicles, Predict the consequences (increase, decrease, no change) the drug would have on each of the following, and give a brief explanation 3. Presynaptic resting membrane potential. 4. Postsynaptic (end plate) potential.
13. During skeletal musele contraction, whet substance does the sarcoplasmic reticulum store and release? A. acetyicholine B. sodium D. calcium 34. What stimalates the sarcoplasmic reticulum (SR) to release this chemical? A. the voltage change from the muscular action potential traveling down the transverse (1) tubules B. the binding of acetylcholine to ligand-gated channels in the transverse tubules C. direct stimulus from the neural action potential D, the binding of myosin to actin 35. Transverse (T) tubales are extensions of...