Question

Inhibition of acetylcholine esterase at the neuromuscular junction would result in which of the following? a)...

Inhibition of acetylcholine esterase at the neuromuscular junction would result in which of the following?

a) No change in muscle contraction frequency

b) Increased crossbridge formation

c) Decreased Na+ influx

d) Decreased Ca2+ release from the sarcoplasmic reticulum

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Answer #1

Answer b. Increased cross bridge formation.

acetylcholine esterase breaks down acetylcholine present in the synapse. Acetylcholine binds to ligand gated sodium channels and causes depolarisation in the post synaptic membrane.
Inhibition of acetylcholinesterase will lead to increase in the concentration of acetylcholine in the synapse.
Hence, the muscle will be continuously depolarised. This will lead to formation of cross bridges between the myosin and actin filament.

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