please help with this mechanism. thanks!
Please help with this one along with the mechanism,
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OEt 1. NaoEt 2.0
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Q4. Please write the detailed mechanism for the following reaction. Please draw ALL CURVY ARROWS charges and electrons. Explain using mechanism which will be major product A or B. (9 pts) Hount . Et and X
Write the mechanism of the PLP-dependent transamination reaction of glutamate and oxaloacetate to yicld α-ketoglutarate plus aspartate. 5.3
The molecule 1, is well known mechanism based inhibitor for one of the PLP containing enzyme. The molecule can adopt either pathway A or B, and can lead to I or II adduct formation. One adduct was formed from 1 covalently linked to pyridoxal 5-phosphate (PLP) (I) while the other adduct was formed with the inhibitor covalently linked to Lysine246, the active site lysine. NH 0 o,po HN н. Lys HN Co.
i
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Write the complete stepwise mechanism for the acid catalyzed hydrolysis of the compound shown. Show all intermediates, indicate with curved arrows the movement of electrons and show all formal charges and lone pairs of electrons where relevant
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VI You are studying the mechanism of catalysis for an enzyme and find that mutating an active site lysine to glutamate has no effect on initial binding, but it significantly decreases the rate at which the enzyme catalyzes its reaction. Predict how this mutation (Lys Glu) is affecting catalytic rate in three sentences or fewer. (Hint, what might the lysine be doing to facilitate catalysis?) LMS stabilizes transition State
Please, provide the step by step mechanism.
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Problem: Please provide the step-by-step mechanism for the transformation shown below: H3O+ ОН H2O
Please show detailed arrow-pushing
mechanism.
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OH B) Please provide a mechanism for the below transformation (8 points). NaoMe Y MeOH, Heat MeOH, Heat
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oH ANAH ii. Cor 2.
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