Question

Na 1. Br CH2-Ph 2. Ph 6M HC OH он NH CI NHy CI NH d -Sy2 Nucleophilic substitution Nucleophilic subs at carbonyl(acyl Xfer) a Electrophilic addition b- E2 Elimination e-Syl Nucleophilic substitution e Electrophilic aromatic substitution h Conjugate (nucleophilic) addn r-Carbonyl nucleophilie addn Identify the mechanism by which each of the reactions above proceeds from among the mechanisms listed. Use the letters a - i for your answers. 2. Submit Answer Ratry Entiro Group
0 1. Cl 0 OMe 。 OMe O OMe KOt-Bu Meo t-BuOH Meo Ci Cl 2. Griseofulvin (a naturally occuring antibiotic) a Electrophilic addition b E2 Elimination e-Syl Nucleophilic substitution d Sy2 Nucleophilic substitution -Nucleophilic subs at carbonyl(acyl Xfer) e Electrophilic aromatic substitution h-Conjugate (nucleophilic) addn f-Carbonyl nucleophilic addn Identify the mechanism by which each of the reactions above proceeds from among the mechanisms listed. Use the letters a i for your answers 2.
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Answer #1

Page 1

1. Ans: d (carbanion nucleophile is substituting bromine nucleophile, strong nucleophile prefers Sn2)

2. Ans: g (Amine nucleophile is substituted by hydroxyl nucleophile at carbonyl).

Page 2

1. Ans: g (Chlorine nucleophile is substituted by ethoxide nucleophile at carbonyl).

2. Ans: h (The reaction is double Michael addition).

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