Homework Answers
This synthesis can be carried out just by Claisen ester condensation. Also note that the only carbon source used is ethanol. The other reagents that have been used here are generated from ethanol alone.
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Complete Multi step synthesis:
This one is for extra credit. Hint: With Claisen and acetoacetic ester...
28- The following molecules can be formed by either: Michael Reaction; Enamine Acylation; Acetoacetic Ester Synthesis;...
28- The following molecules can be formed by either: Michael Reaction; Enamine Acylation; Acetoacetic Ester Synthesis; Michael Addition; Malonic Ester Synthesis; Robinson Annulation; Aldol Condensation; Claisen Condensation; Intramolecular Aldol Condensation; Dieckmann Condensation or a Combination of two of the above listed reaction. In each case write the proper of the reaction on the line and dissect the product into appropriate starting material. In some cases there might only be one starting material. You may use any one of the above...
4 Complete one of the extra credit (4 pts). two syntheses below. (4 pts) if you complete both, it...
4 Complete one of the extra credit (4 pts). two syntheses below. (4 pts) if you complete both, it will be treated as (only carbon source) from s. Outline a selective synthesis of the following dipeptide from the appropriate amino acids (8 ps) NH2
4 Complete one of the extra credit (4 pts). two syntheses below. (4 pts) if you complete both, it will be treated as (only carbon source) from s. Outline a selective synthesis of the following dipeptide...
The acetoacetic ester synthesis is a carbonyl alkylation reaction. It is used to prepare methyl ketones...
The acetoacetic ester synthesis is a carbonyl alkylation reaction. It is used to prepare methyl ketones from primary alkyl halides, lengthening the carbon chain by three atoms. Thus, the product can be visualized as being a "substituted acetone." The reaction consists of three steps: generation of the enolate anion followed by S2 reaction with a primary alkyl halide, ester hydrolysis under acid conditions, and decarboxylation. 1. NaOEt 2. H2O* 3. heat Br + - H₃C + CO2 + ETOH Hc...
9. (7) Write a complete multi-step synthetic route for the following transformations, using only the given...
9. (7) Write a complete multi-step synthetic route for the following transformations, using only the given starting material(s) as the sole source(s) of carbon. You do not have to show the synthesis of solvents or reagents if they are not incorporated into the final product. Clearly (in) Show all intermediate steps and reagents, but do not show any mechanisms or transition states. (24 points): a) Y. I-oyar onbino - we
The Claisen condensation can be used as one step in the synthesis of ketones, as illustrated...
The Claisen condensation can be used as one step in the synthesis of ketones, as illustrated by this reaction sequence. Work out this synthesis on a separate sheet of paper, and then draw die structure of compound b. You do not have to consider stereochemistry. Do not include counter-ions. e g.. Na^+, I^-, in your answer.
Organic Chemistry: Question 12 One problem with a synthesis that takes several steps (a multi-step synthesis...
Organic Chemistry:
Question 12 One problem with a synthesis that takes several steps (a multi-step synthesis in the jargon) is that it produces a low overall yield. Imagine each step has a yield of 90%. A 1-step process would have a 90% yield, a 2-step process would yield 0.90 x 0.90 = 81%. What would be the yield of a 6-step process? Show the math.
5. How might you use acetoacetic ester to perform the following synthesis. (10 points). 3 om s nsonbyH o nap9byi 6...
5. How might you use acetoacetic ester to perform the following synthesis. (10 points). 3 om s nsonbyH o nap9byi 6. Use any reagents you wish to perform the following transformation. Hint: the first step is a chem 242L experiment.(10 points) ot stohosa y uoy dr woH 7. How would you perform the following syntheses using eneamines and any chloro compound you want to use. (8 points). olen eta se s au uoy ialin wolt.
Need Help. Will Rate If Complete. Q 8- The following molecules can be formed by either:...
Need Help. Will Rate If Complete.
Q 8- The following molecules can be formed by either: Michael Reaction; Enamine Acylation; Acetoacetic Ester Synthesis; Michael Addition; Malonic Ester Synthesis; Robinson Annulation; Aldol Condensation; Claisen Condensation; Intramolecular Aldol Condensation; Dieckmann Condensation or a Combination of two of the above listed reaction. In each case write the proper of the reaction on the line and dissect the product into appropriate starting material. In some cases there might only be one starting material. You...
Extra Credit Propose an elegant and efficient synthesis of the molecule show below. You may use...
Extra Credit Propose an elegant and efficient synthesis of the molecule show below. You may use alcohols of 4 carbons or less as your only source of carbon. H3C CH3 HBr CHs
Synthesis using Carbonyla-Substitution Chemistry Preamble This experiment involves the synthesis of target molecules using a-substitution chemistry....
Synthesis using Carbonyla-Substitution Chemistry Preamble This experiment involves the synthesis of target molecules using a-substitution chemistry. You are assigned two target molecules, one of which is best synthesized by an alkylation approach, while the other is best synthesized by an addition or condensation approach. My two target molecules are number 2 and number 12 in the last page. You must do the following: 1. Perform a retrosynthetic analysis on the two target molecules assigned to you. In each case the...
28- The following molecules can be formed by either: Michael Reaction; Enamine Acylation; Acetoacetic Ester Synthesis; Michael Addition; Malonic Ester Synthesis; Robinson Annulation; Aldol Condensation; Claisen Condensation; Intramolecular Aldol Condensation; Dieckmann Condensation or a Combination of two of the above listed reaction. In each case write the proper of the reaction on the line and dissect the product into appropriate starting material. In some cases there might only be one starting material. You may use any one of the above...
4 Complete one of the extra credit (4 pts). two syntheses below. (4 pts) if you complete both, it will be treated as (only carbon source) from s. Outline a selective synthesis of the following dipeptide from the appropriate amino acids (8 ps) NH2
4 Complete one of the extra credit (4 pts). two syntheses below. (4 pts) if you complete both, it will be treated as (only carbon source) from s. Outline a selective synthesis of the following dipeptide...
The acetoacetic ester synthesis is a carbonyl alkylation reaction. It is used to prepare methyl ketones from primary alkyl halides, lengthening the carbon chain by three atoms. Thus, the product can be visualized as being a "substituted acetone." The reaction consists of three steps: generation of the enolate anion followed by S2 reaction with a primary alkyl halide, ester hydrolysis under acid conditions, and decarboxylation. 1. NaOEt 2. H2O* 3. heat Br + - H₃C + CO2 + ETOH Hc...
9. (7) Write a complete multi-step synthetic route for the following transformations, using only the given starting material(s) as the sole source(s) of carbon. You do not have to show the synthesis of solvents or reagents if they are not incorporated into the final product. Clearly (in) Show all intermediate steps and reagents, but do not show any mechanisms or transition states. (24 points): a) Y. I-oyar onbino - we
The Claisen condensation can be used as one step in the synthesis of ketones, as illustrated by this reaction sequence. Work out this synthesis on a separate sheet of paper, and then draw die structure of compound b. You do not have to consider stereochemistry. Do not include counter-ions. e g.. Na^+, I^-, in your answer.
Organic Chemistry:
Question 12 One problem with a synthesis that takes several steps (a multi-step synthesis in the jargon) is that it produces a low overall yield. Imagine each step has a yield of 90%. A 1-step process would have a 90% yield, a 2-step process would yield 0.90 x 0.90 = 81%. What would be the yield of a 6-step process? Show the math.
5. How might you use acetoacetic ester to perform the following synthesis. (10 points). 3 om s nsonbyH o nap9byi 6. Use any reagents you wish to perform the following transformation. Hint: the first step is a chem 242L experiment.(10 points) ot stohosa y uoy dr woH 7. How would you perform the following syntheses using eneamines and any chloro compound you want to use. (8 points). olen eta se s au uoy ialin wolt.
Need Help. Will Rate If Complete.
Q 8- The following molecules can be formed by either: Michael Reaction; Enamine Acylation; Acetoacetic Ester Synthesis; Michael Addition; Malonic Ester Synthesis; Robinson Annulation; Aldol Condensation; Claisen Condensation; Intramolecular Aldol Condensation; Dieckmann Condensation or a Combination of two of the above listed reaction. In each case write the proper of the reaction on the line and dissect the product into appropriate starting material. In some cases there might only be one starting material. You...
Extra Credit Propose an elegant and efficient synthesis of the molecule show below. You may use alcohols of 4 carbons or less as your only source of carbon. H3C CH3 HBr CHs
Synthesis using Carbonyla-Substitution Chemistry Preamble This experiment involves the synthesis of target molecules using a-substitution chemistry. You are assigned two target molecules, one of which is best synthesized by an alkylation approach, while the other is best synthesized by an addition or condensation approach. My two target molecules are number 2 and number 12 in the last page. You must do the following: 1. Perform a retrosynthetic analysis on the two target molecules assigned to you. In each case the...
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