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Question 5 1 pts Which of the following is NOT true about the most common scoring matricies? PAM matricies were derived theoretically from a phylogenetic tree based approach to alignment Larger numbers in PAM matricies are more similar Larger numbers in BLOSSUM matricies are more similar BLOSSUM was derived empirically from known alignments, but without considering a tree

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The correct option is: Larger numbers in BLOSSUM matricies are more similar.

Scoring matrices are tools in Bioinformatics used to detemine the similarities between the two alignment or sequences. Most common types include: PAM (Percent Accepted Mutations) and BLOSSUM (Blocks Substitution Matrix). PAM is used to trace evolutionary relationship between closely related protein sequences. BLOSSUM is used to trace relationships between distantly related protein sequences.

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