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7:51 LTE Х BIO 351 TEST #2: Attempt 1 Timed Test nontarget cells destroy aldosterone before it can produce any effect Questio
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3) Their requirement for travel through the bloodstream

Explanation: Steroid and polypeptide hormones both are the secretion of the endocrine glands, hence they require blood to travel to their target tissue and organs.

There are two classes of hormones based on their solubility in Lipid.
1) Lipid soluble hormones :
These are made up of cholesterol and steroid chains. They are soluble in Lipids.
Lipid soluble hormones exert their effect by binding to the receptors present within the cell either in the cytoplasm or in the nucleus.
This is because they can easily diffuse through cell membrane as cell Membrane is composed of phospholipids . Hence from. Like dissolves like phenomenon, lipid can diffuse and dissolve through lipid membranes.

By binding to the nuclear receptor or cytoplasmic receptors, they influence the expression of transcription factors thereby exert their effects.

2) Lipid insoluble hormones :
These are insoluble in lipids. These are made of proteins or polypeptides.
They exert their effect by binding to the receptors on the cell membrane.
They can not penetrate the cell membrane hence they don't require transport protein.

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