Question

Jill's father James has 8 siblings, 5 brothers and 3 sisters. All his siblings and himself suffer from symptoms related to eyes, some even have complete paralysis of eye muscles. James was told that they have a genetic disorder that runs in the family. James' fater is healthy; about mother he does not know- she died at her early 40th. What is the probable pattern of inheritance for this disorder? Select one: a. Autosomal dominant b. Autosomal recessive C. X-linked dominant d. X-linked recessive X e Mitochondrial

Answer 1

Since Jill's father James, along with his 8 siblings, all have some form of the disease, so it is clearly a dominant trait.
Also, since it affects both males and females in equal frequency, we can say it is not sex-linked but autosomal.
Hence, a. Autosomal dominant