Question

Spontaneous replication errors can be caused by all of the following EXCEP A. tautomeric shift. B. wobble base pairing. C. intercalating agents. D. slippage. E. Actually, all of these can cause spontaneous errors. Induced mutations can be caused by all of the following EXCEPT: A. wobble base pairing. B. base analogs. C. intercalating agents. D. oxidation. E. Actually, induced mutations can be caused by all of these. Expanding nucleotide repeats are NOT: A. involved with genetic disorders such as fragile-X syndrome. B. reasonable explanations for the phenomenon of anticipation. C. induced by radiation. D. variable in size of the repeat. E. Actually, they are all of these.

Answer 1

Please find the answers below and reasons in parentheses:

Part 7: Choice E (All of these mechanisms are potential sources of spontaneous mutations and changes in the DNA sequence during replication due to faulty accumlation of wrong nucleotides and thus prevent optimized complementary base pairing)

Part 8: Choice E (An indcued mutation is the kind of mutation which takes place due to external application of a mutagen to the DNA. These mutagengs can be base analogues, alkylating agents, radiations, intercalating agents etc which can induce mutations in the target gene/DNA strand)

Part 9: Choice E (Anticipation is a kind of genetic mutation in which the target gene/chromosome undergoes duplication and constructs a large number of copies of itself such as trisomic syndromes, repetetion of variable segments of the target DNA etc and results in variation of the native DNA in the individuals in response to indcued mutagens such as radiations etc.)