3. Predict whether each of the following reactions is S1, S2, E1, or E2. Give a...
Predict whether the following reaction is E1 or E2 Predict whether the following reaction is E1 or E2. OH HSO4 heat E1 Elcb Does not undergo elimination The following reaction is most likely to proceed by which mechanism? NaOH to the houd H20 0 0
Practice Problems on S, S2 E1 &E2 1. Describe the ollowing chemical reactions as Sl, S2, El & E Draw a curved arow mechanim for each resction CHCHO N ethanol NaSH DMSO SH Кон но DMSO NaNH2 NH3 отв NH3 HN TsO TsO CH CHg Nal CHs acetone
3. Shown below are a series of reactions. Predict the major product for each of them. Remember, you will need to first decide whether the reaction occurs by an SN2, SN1, E2, or E1 before you can determine what the product will be. Label each as SN2, SN1, E2, or E1. Hint: First decide whether S2/E2 or S1/E1 is favored, and then decide whether the reaction pathway goes by a substitution or elimination reaction. SN2 / SN1 E2/E1 Na DMSO,rt...
1. Determine whether the following reactions will go through SN1, SN2, E1, or E2 mechanism a. 1-bromobutane + sodium hydroxide b. 2-chloro-2-methylpentane + sodium hydroxide + heat C. 2,3-dimethyl-3-bromopentane + water d. 2-bromobutane + methanol 2. Draw the major product for the following reactions (draw both products if racemic): NaSH DMSO TsO CHA Nal CH, acetone CH,CH,ONa+ ethanol CH,OH/H-0 Solite Nal (1 equiv.) acetone F CH2CH OH 25°C
4. Predict the products of the following reactions & indicate whether they are most likely to go through an SN2, SN1, E1, or E2 mechanism. NaCN DMSO NaOH CH3OH heat Only one product is formed in the following E2 elimination reaction. Draw an arrow-pushing mechanism for the reaction and provide the correct product structure. Include a 3-D drawing (chair conformation) displaying proper stereochemistry of the transition state to explain formation of only the major product. CH3 •Br NaOCH3 ~"'CHS
1. Predict whether the following reactions are likely to proceed by an E1 or E2 mechanism. PLEASE show the mechanism and product of the reaction!!!! 2. Explain each prediction. Predicting mechanisms: E1 or E2? 1. Predict whether the following reactions are likely to proceed by an El or E2 mechanism. 2. Explain each prediction. Br co KOH H2O Br CH,CH,OH Br CH2CH OH CH,0/CH,OH Br
For each of the following reactions: (1) Draw all of the organic product(s) that would be formed, and (2) label each product as formed via S1, S2. E1, or E2. For elimination products, label as major or minor. Pay close attention to regiochemistry, stereochemistry, and whether carbocation rearrangements would occur. - DBN ci Br H20 B A C CH3OH acetone NaOH D Br DMSO
3. Identify the major products (only) that are expected for each of the following reactions (20pts): Naci DMSO -BUOK FROH Heat NaOH NaSH Br NaoMe
1. (20 points) Provide the products for the following reactions. Provide stereochemistry where necessary. Determine whether they are SN2, S1, E2, E1, or Elcb where necessary. NO NEED FOR MECHANISMS. Br NaOCH.CH diethyl ether KOBU DMSO heat NaCN THF
2. Predict whether the reaction willl go by SN1, SN2, E1, or E2, or some combination of these. Explain. Also give the products with correct stereochemistry if applicable. SoI Na CN Br dimethyl sulfoxide (DMSO) CI CH,онн,0 Br CH3S Na* + acetone