Question

Q1: Describe the ways in which follicular dendritic cells (FDCs) are similar to subcapsular sinus macrophages.

Q2: Explain why expression of CD40 ligand by T_FH cells is important in the boundary area of primary follicles in secondary lymphoid tissue as it relates to the targeted delivery of secreted cytokines to the B-cell surface.

Q3: (i) .What is the main effector function of IgM antibody? (ii) Why is IgM efficient at (i) preventing blood-borne infections and (ii) fixing complement, but (iii) less efficient than other antibody classes in inducing phagocytosis of immune complexes?

Answer 1

Answer :)

Follicular dendritic cells have the exclusive ability to bind and keep native antigen in the form of B-cell follicles and that is for long durations. Therefore, these cells shape the B-cell antigenome. However, in the absence of B cells, FDCs do not form. On the other hand, subcapsular sinus (SCS) macrophages clear lymph nodes from various infections. Therefore, both FDCs and SCS macrophages have similar function to clear infections whether directly or indirectly.

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