Question

Part D The figure below shows 5-methylcytosine, a pyrimidine that arises naturaly in DNA when cellular enzymes methylate cytosine. Why is the presence of this base likely to increase the probability of a mutation? 5-Methylcytosine Drag the terms on the left to the appropriate blanks on the right to complete the sentences Reset Heip adenine guanine thymine cytosine deamination The base 5-methylicylosine yiolds and bocause it is a naturally occurring base. thero is no mechanism to detect and oxcise these newly generated of 5- methyloytosine wil therefore go unrepaired depurination Submit

Answer 1

5 methyl cytosine is a hotspot of spontaneous mutation. It is generated by methylase enzyme that adds a methyl groups to certain cytosine residues at specific sites in DNA. The cytosine base suffers deamination at appreciable frequency to thymine.

1. thymine 2. deamination