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in li AaBbCcDdEe AaBbCcDdEe AaBbCcDc AaBbCcDdE Heading 1 Heading 2 Normal No Spacing 4. In the following reaction sequence, what is the purpose of the (CH),SICI? ОН 1. O Br (CH3)3 SICI (CH3CH2)2N Mg/ ether TBAF B 2. Hző D 5. Draw the product for the following reaction (show stereochemistry) OH PBP3 6. Provide a curved arrow mechanism for the formation of the product. OH .CH HC HBr CH HC CH CH Focus

Answer 1

Answer osi(CH3)3 OH 4 Br Bor A Z (CH₂)₂sic (CA),N? protection of alcohol rakes Place osilk) li mg /ether osikth) 3. .Ong Br Ang Br Imo Nucleophitic addition to the carbonyl Centre, Osi(CH3)3 OH TBAF de protonation of alcohol. oranss. OH OH used for ((th) sice is A protection of alcohol. If we protected alcohol the grignard reagent will react with alcohol produce akane. CScanned with CamScanner

OH Bro 5 PBrz Mechanism O piora Paper A Bor - OH act as a hucheophik o BY SNg reaction takes place Bro inversion of cm figuration) ÖH 60th cthy Hon Hae CHB the CH ch, oxygen is protmated. water is good leaving group. CH3 CH3 the Hoe И cthy Br aetas (ан, it is migrated Carbocation formd. a nucleophice 1 Br due to more stable attack to the Cambocation Centre He сть -Bor cm CScanned with CamScanner