1. The drinking water standard for tetrachloroethylene is 0.005 mg/L, The potency factor for tetrachloroethylene is...
1.
The drinking water standard for tetrachloroethylene is 0.005 mg/L, The potency factor for tetrachloroethylene is 5.1*10^-2 (mg/kg-day)^-1. What lifetime risk would this pose?
Assume 30 year exposure for 350 days per year.
2.
•Suppose a 70-kg man is exposed to 0.1 mg/m3 o etrachloroethylene in the air at his workplace. If he inhales 1m3/hr, 8 hours per day, 5 days per week, 50 weeks per year, for 30 years, and if tetrachloroethylene has an absorption factor of 90 percent and an inhalation potency of 2*10-3 (mg/kg-day)-1, what would be his lifetime cancer risk? •What would the risk be to a 50-kg woman similarly exposed?
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1.
The drinking water standard for tetrachloroethylene is 0.005
mg/L, The potency factor for tetrachloroethylene is...
The drinking water standard for tetrachloroethylene is 0.005 mg/L. The potency factor for tetrachloroethylene is 5.1*10^-2(mg/kg-day)-1....
The drinking water standard for tetrachloroethylene is 0.005 mg/L. The potency factor for tetrachloroethylene is 5.1*10^-2(mg/kg-day)-1. What lifetime risk would this pose? Assume 30 year exposure for 350 days per year
20/27OBLEM: Suppose drinking water contains 1 mg/l of toluene and 0.01 mg/l of tetrachloroethylene (C2C4). A...
20/27OBLEM: Suppose drinking water contains 1 mg/l of toluene and 0.01 mg/l of tetrachloroethylene (C2C4). A 70 kg adult drinks 2 t/day of this water for 10 years. a) Assess HR and evaluate HR. Was this a safe level of exposure? b) C2C4 is a carcinogen. What would be the carcinogenic risk faced by a person drinking it. Would it be less than 106 (goal)? RfDtoluene 0.2 mg/kg.day RfDc:ci 0.0 mg/kg.day PFc.c 5.1 x 10-2 (mg/kg-day)
20/27OBLEM: Suppose drinking water...
Q.3 The drinking water standard for 2,3,7,8-TCDD (dioxin) is 3×10-8 mg/L. Using EPA exposure factors for...
Q.3 The drinking water standard for 2,3,7,8-TCDD (dioxin) is 3×10-8 mg/L. Using EPA exposure factors for residential consumption, what lifetime risk would this pose? Note that the potency factor of dioxin is 1.56×105 mg/kg-d.
Chronic dally irve. It can also be FIGURE 4.10 The potency factor is the slope of...
Chronic dally irve. It can also be FIGURE 4.10 The potency factor is the slope of the dose-response curve. It thought of as the risk that corresponds to a chronic daily intake of 1 mg/kg-da Potency Factory Inhalation Row (mg/kg-dayi 50 2.9 x 10-2 6.11 6.1 8.1 x 10-2 - 41 TABLE 4.9 Toxicity Data for Selected Potential Carcinogens Potency Factor Oral Route Category (mg/kg-day) Chemical 1.75 Arsenic 2.9 X 10-2 Benzene 11.5 Benzol(a)pyrene Cadmium 0.13 Carbon tetrachloride 6.1 X...
A 70-kg individual drinks 2 L/day of water containing 0.015 mg/L of tetrachloroethylene for 20 years....
A 70-kg individual drinks 2 L/day of water containing 0.015 mg/L of tetrachloroethylene for 20 years. (a) Find the hazard quotient for this exposure. (b) Find the cancer risk. (c) If the individual drinks this water for 30 years instead of just 20, recomputed the hazard quotient and the cancer risk. A man works in an Aluminum smelter for 10 years. The drinking water in the smelter contains 0.015 mg/L arsenic and 0.80 mg/L methylene chloride. His only exposure to...
1. Chloroform (CHCl3) has a Drinking Water standard concentration of 0.10 mg/L . a. What is...
1. Chloroform (CHCl3) has a Drinking Water standard concentration of 0.10 mg/L . a. What is this concentration expressed as parts per million (ppm)? b. Typical consumption Risk Analysis assumes the average human drinks 2.2 L/day for 70 years. How many grams of CHCl3 would the average human consume during a lifetime at the Drinking Water standard concentration? 2. The Air Quality Standard for sulfur dioxide (SO2) is 0.04 ppm. Express this as mg/m3 at 1 atm and 25oC.
when a cities drinking water is disinfected by chlorine , an undesired by -product chloroform (CHCL3)...
when a cities drinking water is disinfected by chlorine , an undesired by -product chloroform (CHCL3) can be formed. Assume a 73kg person drinks 2.7L/day of water over her/his lifetime. (70years) with a chloroform concentration of 2.98mg/l with a potency factor of 0.007(kg.day/mg). Determine the increased cancer risk for this person. Please give the answer to four decimal places.
Chloroform (CHCI3) has a Drinking Water standard concentration of 0.10 mg/L What is this concentration expressed as par...
Chloroform (CHCI3) has a Drinking Water standard concentration of 0.10 mg/L What is this concentration expressed as parts per million (ppm)? Typical consumption Risk Analysis L/day for 70 years. How many grams of CHCI3 would the average human 1. a. b. assumes the average human drinks 2.2 during a lifetime at the Drinking Water standard concentration? consume Find the Volume of 1 mole of an ideal gas at 1.2 atm and 80°C 2. The Air Quality Standard for sulfur dioxide...
Example Chloroform is sometimes formed incidentally in drinking water plants. Suppose a 70 kg person drinks...
Example Chloroform is sometimes formed incidentally in drinking water plants. Suppose a 70 kg person drinks 2 L of water per day from water with 0.10 mg/L chloroform. Find the upper bound cancer risk for this person, and estimate the number of extra deaths caused in a city of 500,000 with this exposure risk. How does this compare with the cancer risk in the US, which is 189/100,000/year?
the lifetime cancer risk (per million) for an adult from eating fish taken from PF 1.75...
the lifetime cancer risk (per million) for an adult from eating fish taken from PF 1.75 (oral) and 50 on) in (mg/kg-day): Daily intake of fish 54 g body weight 70 kg (adult) and 15 kg waters containing 0,1 mg/l of Arsenic. 13) Risk CDI x PF: CDI (concentration)x (intake rate)x (exponure) (body weight)x (70 )x (365 29 (chil F Bloconcentration factor for Arsenic 44 /kg: Exposure (350 day/year) x (30 year)l
20/27OBLEM: Suppose drinking water contains 1 mg/l of toluene and 0.01 mg/l of tetrachloroethylene (C2C4). A 70 kg adult drinks 2 t/day of this water for 10 years. a) Assess HR and evaluate HR. Was this a safe level of exposure? b) C2C4 is a carcinogen. What would be the carcinogenic risk faced by a person drinking it. Would it be less than 106 (goal)? RfDtoluene 0.2 mg/kg.day RfDc:ci 0.0 mg/kg.day PFc.c 5.1 x 10-2 (mg/kg-day)
20/27OBLEM: Suppose drinking water...
Chronic dally irve. It can also be FIGURE 4.10 The potency factor is the slope of the dose-response curve. It thought of as the risk that corresponds to a chronic daily intake of 1 mg/kg-da Potency Factory Inhalation Row (mg/kg-dayi 50 2.9 x 10-2 6.11 6.1 8.1 x 10-2 - 41 TABLE 4.9 Toxicity Data for Selected Potential Carcinogens Potency Factor Oral Route Category (mg/kg-day) Chemical 1.75 Arsenic 2.9 X 10-2 Benzene 11.5 Benzol(a)pyrene Cadmium 0.13 Carbon tetrachloride 6.1 X...
A 70-kg individual drinks 2 L/day of water containing 0.015 mg/L of tetrachloroethylene for 20 years. (a) Find the hazard quotient for this exposure. (b) Find the cancer risk. (c) If the individual drinks this water for 30 years instead of just 20, recomputed the hazard quotient and the cancer risk. A man works in an Aluminum smelter for 10 years. The drinking water in the smelter contains 0.015 mg/L arsenic and 0.80 mg/L methylene chloride. His only exposure to...
Chloroform (CHCI3) has a Drinking Water standard concentration of 0.10 mg/L What is this concentration expressed as parts per million (ppm)? Typical consumption Risk Analysis L/day for 70 years. How many grams of CHCI3 would the average human 1. a. b. assumes the average human drinks 2.2 during a lifetime at the Drinking Water standard concentration? consume Find the Volume of 1 mole of an ideal gas at 1.2 atm and 80°C 2. The Air Quality Standard for sulfur dioxide...
Example Chloroform is sometimes formed incidentally in drinking water plants. Suppose a 70 kg person drinks 2 L of water per day from water with 0.10 mg/L chloroform. Find the upper bound cancer risk for this person, and estimate the number of extra deaths caused in a city of 500,000 with this exposure risk. How does this compare with the cancer risk in the US, which is 189/100,000/year?
the lifetime cancer risk (per million) for an adult from eating fish taken from PF 1.75 (oral) and 50 on) in (mg/kg-day): Daily intake of fish 54 g body weight 70 kg (adult) and 15 kg waters containing 0,1 mg/l of Arsenic. 13) Risk CDI x PF: CDI (concentration)x (intake rate)x (exponure) (body weight)x (70 )x (365 29 (chil F Bloconcentration factor for Arsenic 44 /kg: Exposure (350 day/year) x (30 year)l
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