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2b. (4 pts) Briefly describe how the location of the DC and their surface molecule expression changes during an infection.

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When pathogen enters or invade inside body than immature dendritic cell migrate through blood stream from bone marrow to infected site and engulf matter or antigen by phagocytosis.

Immature DC continuously ingest large amount of fluid and its contents. This process is known as macropinocytosis.

After taking pathogen inside they are capable of activating T lymphocytes. DC express antigen on their surface to activate T cells. Thus they are now mature DC.

Cells which have antigen on their surface which activates T lymphocytes. This cells are known as antigen presenting cell.

The main role of DC is not to clear all pathogens but to activate other T lymphocytes to kill all pathogens. Mature DC express antigen on their surface and activate other lymphocytes.

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