Question

the role of BMP signaling in the interdigital cell death was done in experiment by implanting protein soaked beads in the hindlimbs of chick embryos. For each , describe the impact of implanting the bead on the pattern of interdigital cell death, describe the impact of implanting the bead on digit morphology and explain whether or not BMP signaling is active in the interdigital region

(a) A bead soaked in BMP2 is implanted in the interdigital space.
(b) A bead soaked in Grrmlin is implanted in the interdigital space (c) a bead soaked in PBS is implanted in the interdigital space

duck limb has no bmp inhibition so no apoptosis while chick has that bmp so undergo apoptosis

Answer 1

Interdigital cell death is a physiological regression process responsible for sculpturing the digits in the embryonic vertebrate limb. As we know that the interdigital cell death leads to the regression of soft tissue between embryonic digits in vertebrates ,, BMP receptor is used here as a to block BMP signalling as we know that BMP (Bone Morphogenetic Protein) are the group of singalling molecules that belongs to the Transforming Growth Factor BETA . BMPs is important for the embryogenesis and development and also for maintaining tissue homeostasis,

in chick embryos BMP signalling helps in primitive streak formation in pregastrula stage, so when limb has no BMP signalling then their is absence of notochord.