Question

how do isocyanide based multicomponent reactions help with arthritis?

Answer 1

Multicomponent reactions (MCR) are powerful tools for the rapid generation of molecular diversity and complexity. In a typical multicomponent process, more than two components are combined in a single reaction, thereby providing an operationally effective and highly modular approach towards the synthesis of structurally diverse molecular entities. Among the MCRs, the isocyanide-based multicomponent reactions (IMCRs) are most relevant for the synthesis of peptıdomiumetics because thev provide peptıde-like products Isocvanide-based reactions form the backbone of today's MCR chemistry, and the most common examples are: the Passerini reaction and the Ugi reaction Using this MCR chemistry, so many drug analoge for rheumatic arthritis have synthesised. this is helped a lot to develop an effective drug for arthritis Many opportunities exist to employ MCR chemistry in the kinase field. A p38 kinase inhibitor SB220025 was recently clinically evaluated in phase III for rheumatoid arthritis