Question

Digoxin is an inhibitor of Na^+/K^+ ATPase that is used to treat irregular heartbeat(medical term: atrial fibrillation). Digoxin slows the heartbeat by raising Intracellular calcium levels. What Is the most reasonable explanation for how digoxin can raise intracellular calcium concentrations through Inhibiting Na^+/K^+ ATPase? Multiple Choice Na^-/K^- ATPase acts to shuttle Ca^2- out of the cell. As a result, Intracellular Ca^2- levels Increase. Inhibiting Na^-/K^- ATPase results In a higher than normal Intracellular Na^- concentration. This reduces the effectiveness of the Na^-/Ca^2- antiporter. As a result. Intracellular a Ca^2- levels Increase. Inhibiting Na^-/K^- ATPase results In a lower than normal Intracellular Na^- concentration. This reduces the effectiveness of the Na^-/Ca^2- antiporter. As a result, Intracellular Ca^2- levels Increase. Inhibiting Na^-/K^- ATPase results in a lower than normal extracellular K^- concentration. This Increases the effectiveness of a K^-/Ca^2- symporter that drives the influx of both K^- and Ca^2- As a result, Intracellular Ca^2- levels Increase.

Answer 1

Digoxin is an inhibitor of NaK ATPase that is used to treat irregular heartbeats (medical term: atrial fibrillation). Digoxin slows the heartbeat by raising Intracellular calcium levels. What is the most reasonable explanation for how digoxin can ralse intracellular calcium concentrations through inhibiting Na K ATPase? Digoxin inhibits Na+/K+ ATPase, which results in a higher than normal intracellular Na+ concetration. So, the Na+/Ca+2 exchange will be decrased, the calcium remain inside the cell. This results in increased force of contraction Multiple Choice Na K ATPase acts to shuttle Ca2- out of the cell. Digoxin Inhibits Na K ATPase, preventing it from shuttling Ca2 out of the cell. As a result, Inraeular Ca 2- levels increase inhibiting NaK ATPase results in a higher than normal Intracellular Na" concentration. This reduces the effectiveness of the Na/Ca2 antiporter. As a result, Intracellular Ca2levels Increase. inhibiting Na IK" ATPase results in a lower than normal Intracellular Na concentration. This reduces the effectiveness of the Na Ca2 antiporter. As a result, Intracellular Ca2 levels Increase Inhibiting Na ATPase results In a lower than normal extracellular K concentration. This Increases the effectiveness of a KC and Ca2-. As a result, Intracellular Ca2-levels Increase. symporter that drives the Influx of both K