how do failing of cell cycle regulation result in cancer?
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Cancer and Gene Regulation Why is a cell cycle control system needed for cell division? What happens when cells do NOT respond to the cell cycle control system and divide excessively? Tumor Proto-oncogeno (for protein that stimulates coll division) 6 Y DNA Benign Tumor= Mutation withln a control region of DNA Malignant Tumor Mutated promoter Metastasis Normal growth-stimulating protein in excess Oncogene Tumor-Suppressor Genes Proto-oncogene utled tara gese Samor-auppresr gane Many proto-oncogenes code for growth factors /Deletive nonimenig Normel grewt...
Explain how imperfect microtubule organization and cell cycle regulation can lead to disease.
a. To cause cancer, proto-oncogenes require considered mally, tumor suppressor genes inhibit the cell cycle. How do mutated tumor suppressor Ben cell cycle? allele(s) to be mutated and therefore are - The mutation results in a of function. nor suppressor genes affect the a. To cause cancer, tumor suppressor genes require allele(s) to be mutated and therefore are considered - The mutation results in a _ _ of function.
Describe how cell cycle control is related to cancer. Include a description of the G1 checkpoint and signal transduction.
Why is it important to understand the cell cycle when considering cancer? In your answer, explain how a conventional medical treatment for cancer takes advantage of the cell cycle of cancerous cells
6. What is cancer? In your answer, discuss how a normal cell differs from a cancer cell, including specific examples regarding differences in the cell cycle.
Cancer cells often lack normal DNA damage response and cell-cycle control mechanisms. Why does this make them more susceptible to DNA-damaging chemotherapies? O Cancer cells will arrest in the cycle and will not grow further O Cancer cells with activating mutations in Ras will amplify the damage through the Ras signaling pathway Cancer cells might ignore the normal mechanisms that halt the cell cycle in response to damage, and subsequent division with damage leads to death, O Cancer cells have...
CHAPTER 12 THE CELL CYCLE Study Questions The Key Roles of Cell Division 1. Why do cells divide? 2. What are the major events of eukaryotic cell division that enable the genome of one cell to be passed on to two daughter cells? 3. How do chromosomal numbers change throughout the human life cycle? The Mitotic Cell Cycle 4. What are the phases of the cell cycle? What is the sequence of events that occurs during each phase? 5. What...
13. Within the "Cell Cycle Regulators and Cancer" section, click on the "stop sign" inhibitory symbol in G1 phase of the cell cycle diagram. a. The p53 and Rb genes are proto-oncogenes/tumor suppressors (highlight one of the two preceding terms). Justify your choice in 1-3 sentences by describing the functions of the proteins encoded by these genes. Justification: b. Why do we consider potentially cancer-causing mutations in these genes to be recessive? Response: c. Under what circumstances do we consider...
Do you feel that an increased understanding of the regulatory mechanism of the cell cycle increases our understanding of how cancer develops?