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Question 5 (5 pts): For what function has evolution favored the preservation of CpG dinucleotides at gene promoters? Question 6 (10 pts): What is meant by saying that regulatory activity at gene promoters alone cannot be responsible for a cells overall program of cell-type differentiation? Question 7 (5 pts): Why is phosphorylation of certain serine residues on the C-terminal domain of RNA Pol II so important during gene transcription? Question 8 (5 pts): Why is alternative RNA splicing so important for determining types of proteins in our bodies? Question 9 (5 pts): How can the effects of transcription factors bound to a site along DNA have an effect on a gene promoter many tens of kilobases away? Question 10 (5 pts): In the RNAi pathway, what is the purpose of loading a small RNA fragment onto the RISC protein complex?
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