Question

17. Biopsies from 277 bladder cancer patients were analyzed for plakoglobin expression, a 1.0 protein found in desmosomes. The biopsies were grouped into two categories, either high expression or low expression in the tumor. The patients' overall survival was then plotted as a function of time (years) after biopsy. On the Y- E 6 axis, 1.0 represents 100% survival, 0.8 represents 80% survival, etc. Given that the patients in this experiment died from bladder cancer, why do you suppose the high expression and low expression groups have different prognoses? 0.0 Plakoglobin expression (n 277) High expression (n-127) Low expression (n> 150) p- 0.02 Time (years) 10

Biopsies from 277 bladder cancer patients were analyzed for plakoglobin expression, a protein found in desmosomes. The biopsies were grouped into two categories, either high expression or low expression in the tumor. The patients’ overall survival was then plotted as a function of time (years) after biopsy. On the Yaxis, 1.0 represents 100% survival, 0.8 represents 80% survival, etc. Given that the patients in this experiment died from bladder cancer, why do you suppose the high expression and low expression groups have different prognoses?

Answer 1

Ans: Based upon the plot, The high  plakoglobin expression is correlated to high survival rate and low expression rate correlated to low survival rate, so we can suppose the high expression and low expression groups have different prognoses.