Question

26. In case study 1 we looked at pneumonia caused by the Gram-positive bacteria Streptococcus pneumoniae and the yeast Candida albicans. A. Draw picture of each cell. A complete answer will include the major internal and external structures with special attention to features that are used to characterize these cells (8pts). B. Indicate an antibiotic that could be used to selectively target each of these organisms and describe its mode of action (2.5pts).

Answer 1

26.

(A)

Below is a coloured and well-labelled diagram of Streptococcus pneumoniae.

#streptococcus pneumoniae :- ATP-binding L transporter. I cassette . ::. lyta DIAMO pnumolis metal bindin protein. Capsule. -capsuk. - cell membrane Ps 4 Piatt 'Eno te Pava- ONAIS MIN Pinar Lipoleichoic auid sortases 711 pspc Hespa LPTG-anchored nuraminidase. Рxotei Choline binding protein 11 PPP psp A & pspc = pneumococcal surface proteins Ase. Para = pneumococcal adhesion and virulence A. Сио - Смоле. lyt = autolysin A. Psa A= Phen mococial surface antigen Ai Platz Pneumococal iron acquisitim A. Pin A = prenmococal iron uptake A.

Below is a well-labelled diagram of Candida albicans:

#Candida albivans Yeast cello Endoplasmit I Reticulum Mitochondria. septin sing, Gilgi body. fimbral. Microa tubule. 3 VID KIT Vaendle. 11 vetice. I Cellwall plasmamenbrue. Nuckar Nuelens. Nueledus. pore.

(B)

Antibiotic for Streptococcus pneumoniae: Streptomycin. It is a basic trisaccharide that binds with the 30S subunit of the S. pneumoniae ribosome and causes misreading of mRNA

Antibiotic for Candida albicans: Cycloheximide. It blocks the peptidyl transferase of 80S ribosome of the C. albicans and hence stops the process of translation

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