A C-D (carbon-deuterium) bond is harder to break than a C-H bond, and, consequently, reactions in...
A C-D (carbon-deuterium) bond is harder to break than a C-H bond, and, consequently, reactions in which C-D bonds are broken proceed more slowly than reactions in which C-H bonds are broken. What mechanistic information comes from the observation that perdeuterated benzene, C6D6, is nitrated at the SAME rate as normal benzene, C6H6 (k1=k2)? HINT: write the mechanism for the nitration of benzene.
Homework Answers
The mechanism for the nitration of benzene is as shown.
Since, perdeuterated benzene, C6D6, is nitrated at the SAME rate as normal benzene, C6H6 (k1=k2), the C-D bond is not broken in the rate determining step. The rate determining step is the attack of pi elecrons of benzene to the nitronium ion.
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A C-D (carbon-deuterium) bond is harder to break than a C-H
bond, and, consequently, reactions in...
The chemistry of deuterium is nearly identical to that of hydrogen. One area of difference is...
The chemistry of deuterium is nearly identical to that of
hydrogen. One area of difference is that C-D bonds are about 1.2
kcal/mol stronger than C-H bonds. As a result, reaction rates tend
to be slower if a C-D (as opposed to C-H) bond is broken in a
rate-limiting step. This important fact can lead to great
mechanistic insight and is called the kinetic isotope effect.
a) Propose a mechanism to explain each product in the following
reaction.
b) When...
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The chemistry of deuterium is nearly identical to that of
hydrogen. One area of difference is that C-D bonds are about 1.2
kcal/mol stronger than C-H bonds. As a result, reaction rates tend
to be slower if a C-D (as opposed to C-H) bond is broken in a
rate-limiting step. This important fact can lead to great
mechanistic insight and is called the kinetic isotope effect.
a) Propose a mechanism to explain each product in the following
reaction.
b) When...
Fatty Acid Metabolism. The reactions of the fatty acid spiral are shown below. Use the description on the left side of the page to classify the reactions and fill in the boxes on the right side of the page Activation Step. The activation of the fatty acid begins by the addition of CoA which will carry the fatty acid from the cytosol into the mitochondria. The product, which is a fatty acid with a CoA attached, is known as a...
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