The cancer drug 5-fluorouracil is a weak acid with a logP if about -0.6. Which of...
- The cancer drug 5-fluorouracil is a weak acid with a logP if about -0.6. Which of the following is true with respect to the effect of pH on apparent partition coefficient for 5-fluoruracil?
- Papp should increase with increasing pH
- Papp should decrease with increasing pH
- Papp will not change with increasing pH
Homework Answers
according to Henderson Hasselbalch equation : for weak acid Papp = P/ 1+10 pH - pKa
So with the increase of the pH the value of Papp should be decreased.
Papp should decrease with increasing pH .
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