Question

g. Vertebrate dorsal root sensory cells have a Na-dependent action potential. Voltage clamp experiments reveal that the inward Na current is reduced but not eliminated in the presence of TTX. What do you conclude from this results? Describe two experiments to test your conclusion.

Answer 1

Answer :- (9)

Because TTX only blocks 50% of the inward voltage dependent Na+ current, there must be a separate and distinct population of voltage dependent Na+ channels that are TTX-insensitive. To test this end, one could, utilizing voltage cinch, measure the internal current within the sight of TTX (to kill the TTX-touchy Na+ current) and after that expel [Na+ ] to find out whether the staying internal current is conveyed by Na+ .

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