Below are listed some of the top selling drugs along with their clogP and polar surface...
Below are listed some of the top selling drugs along with their clogP and polar surface area (PSA) values. activity cLogP PSA esomeprazole Anti-acid reflux 2.56 72.6 rosuvastatin anticholesterol 0.93 148.7 atorvastatin anticholesterol 4.45 110.0 quetiapine Antipsychotic(CNS) 2.99 48.2 aripiprazole Antidepressant (CNS) 5.31 44.8 duloxetine Antidepressant (CNS) 4.25 21.2 valsartan Hypertension 5.70 106.7 AMS-167 98.7 SCP-123 132.8 Identify privileged structures in each of the molecules listed above. Based on the activity above how does the PSA relate to BBB penetration? Would you expect AMS-167 or SCP123 to be CNS active compounds?