Question

Instructions for short answer questions/calculations: Provide your answer in the space provided. i you require additional space, use the last page and clearly indicate the question number and part. 1. Consider the following two amino acids: AAR) a. Draw the condensation reaction that results in the formation of the dipeptide AAR1 AAR2. (5 po The peptide bond linking amino acids is rigid and planar. Provide a structural explanation for the rigid and planar nature of the peptide bond. (Hint: You will need to draw structures to receive full credit.) (5 points) b. Clearly indicate a φ and a ψ dihedral angles in the dipeptide structure that you drew in part (a), (2 points) c d. Explain how you would use the solid phase peptide synthesis method (Merrifield synthesis) to synthesize AAR1 AAR2. (8 points)

Answer 1