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A patient has a negative indirect antibody screen. The immediate spin in crossmatching is positive/incompatible with some of the units. List FOUR possible reasons for this

A patient has a negative indirect antibody screen. The immediate spin in crossmatching is positive/incompatible with some of the units. List FOUR possible reasons for this

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Answer #1

A negative indirect antibody screen (coombs test) gives positive or incompatible after immediate spin in cross matching, indicates ABO incompatibility.

Reasons can be, the blood samples would have contaminated with other blood samples or double checking the recipient and donor blood group would be efficient.

Next reason might be, if the forward and reverse A reactions are weaker than 4+ for the subgroup A or AB with anti A1.

Due to recent transfusion, the sample might contain passive anti- A or B from ABO incompatible platelets.

It will easily get reacted at room temperature, hence doing the test at lower temperatures might be effective.


answered by: ANURANJAN SARSAM
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