How does ECM or basement membrane slow down initial angiogenesis?
How does ECM or basement membrane slow down initial angiogenesis?
Homework Answers
The process of new capillary blood vessels formation from preexcisting blood vessels is called angiogenesis. at the intial stage of new blood vessel formation , basement membrane, the specialized type IVcollagen and lamininrich connective tissue membrane underlying endothelial cell layer , the interstitial connective tissue matrix , the type I and III collagen rich ground substances , and type II collogen in a cartilage ,are broken down , therefore angiogenesis requires digestion of the ECM barrier underlying the blood vessels endothelial cell layers by MMP's.
The process of new capillary blood vessels formation from preexcisting blood vessels is called angiogenesis. at the intial stage of new blood vessel formation , basement membrane, the specialized type IVcollagen and lamininrich connective tissue membrane underlying endothelial cell layer , the interstitial connective tissue matrix , the type I and III collagen rich ground substances , and type II collogen in a cartilage ,are broken down , therefore angiogenesis requires digestion of the ECM barrier underlying the blood vessels endothelial cell layers by MMP's.
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