pound rather than another isomer. 2. Write a mechanism for the Friedel-Crafts reaction of anisole with...
1. A. Predict the products for the following reaction and write a rational mechanism. OCH3 (CH3CO20 AICI: Mechanism: 1. B. Why are much larger quantities of aluminum chloride required for Friedel-Crafts acylation reactions than for alkylation reactions? T.C. A student reacted anisole with acetic anhydride in dichloromethane using aluminum chloride as a catalyst. The student used the experimental procedure as described in the laboratory manual. At the end of the experiment the student failed to get +- methoxyacetophenone. Give reasons...
ence between a Friedel-Craft alkylation and Acylation. Synthesis of 4-Methoxiacetophenone For this Friedel-Craft acylation we will react Anisole with Acetic Anhydride. Write the mechanism and the structure of the final product. OCH Ald + CH3- CH- --CH, CH-Cl, anisole acetic anhydride a What will be the major product for this reaction? Explain why. b) The presence of the O-Methyl group will favor what positions for the substitution? Post Laboratory Luinld when 55 of anisole react with 0.65 g of acetic
Write out a proposed mechanism for the Friedel-Crafts alkylation reaction of p-xylene to form n-propyl.
Friedel-Crafts Acylation of Ferrocene
H3PO4 DISCUSSION 1. This reaction is done with a 10-fold excess of acetic anhydride, yet the dominant product of the reaction is the mono-acylated compound. Very little 1,1'-diacetylferrocene is formed. a. Why? b. What conditions are necessary to form 1,1'-diacetylferrocene as the main product? c. Why does 1,3-diacetylferrocene not form under these conditions? 2. During workup of the product, water reacts with the excess acetic anhydride to give what side product(s)?
Friedel-Crafts Acylation of Ferrocene "riedel-Crafts reactions are examples of electrophilic aromatic substitution reactions. The eaction involves the substitution of hydrogen on the aromatic ring system by an electrophilic arbon species forming a new carbon-carbon bond. Friedel-Crafts reactions may be used to ntroduce either an alkyl or acyl group. Ferrocene does not undergo addition reactions typical of cyclopentadiene, but undergoes Electrophilic aromatic substitution. The Friedel-Crafts acylation reaction of ferrocene involves he addition of the acylium cation to one of the carbon...
lab
help please!!
#6 FRIEDEL-CRAFTS ACYLATION OF FERROCENE 2. This reaction is done with a 10-fold excess of acetic anhydride, yet the dominant product of the reaction is the mono-acylated compound. Very little 1,1'-diacetylferrocene is formed. a. Why? b. What conditions are necessary to form 1,1'-diacetylferrocene as the main product? c. Why does 1,3-diacetylferrocene not form under these conditions?
Friedel - Craft Acylation Synthesis of 4-Methoxiacetophenone Background Information 1.- What is an electrophilic aromatic substitution? 2.- Give three examples of activating groups. Explain why they activate the ring for substitution. 3.- Give three examples of deactivating groups. Explain why they deactivate the ring for substitution. 4.- Describe the difference between a Friedel-Craft alkylation and Acylation. Synthesis of 4-Methoxiacetophenone For this Friedel-Craft acylation we will react Anisole with Acetic Anhydride. Write the mechanism and the structure of the final product....
2. Complete the mechanism of this Friedel-Crafts reaction below with the correct arrow pushing and missing intermediate. box 1 box 2 [DN] + box 3 ci-Alci [1,2R] [AN] - AICI [AE] box 5 box 4 [DE]
produce the mechanism for the friedel-crafts acylation
reaction. please box the answers for these three questions.
AICI3 AICI: AICI: 2 ?
For number 2, would someone be able to explain the mechanism to
me in words rather than structures?
1. The name acetic anhydride implies that the compound will react with water to form acetic acid. Write the equation for the reaction. - (CH3CO)20 + H20 → 2CH3COOH - Or CH3COOCOCH3 + H2O → 2CH3COOH 2. Propose a mechanism for this reaction (salicylic acid with acetic anhydride). Identify the nucleophile and the electrophile.