In a population of interest, 1 in 2000 women are affected with haemophilia A, an X-linked...
In a population of interest, 1 in 2000 women are affected with haemophilia A, an X-linked recessive condition.
a) What is the carrier frequency in this population for Haemophilia A?
b) What is the expected frequency of men affected with Haemophilia A?
Homework Answers
A) Genotypic frequentcy of disease female is 1/2000=0.0005
The allelic frequency of disease allele (Xh) is √0.0005= 0.0223606798 or 0.022
The allelic frequency of XH is 1- Xh = 1-0.22= 0.978
Carrier frequency is 2×XH× Xh = 2×0.978×0.022= 0.043032
B) The expected frequency of affected male is Xh= 0.0223606798 or 0.022 on round off upto three decimal place.
Because the genotype of affected male has XhY. Affected male has one Xh allele only.
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