if 1/40,000 individuals are affected by an autosomal recessive disorder in a population in HWE, what is the probability a carrier and someone with no family history will have an affected child?
if 1/40,000 individuals are affected by an autosomal recessive disorder in a population in HWE, what is the probability a carrier and someone with no family history will have an affected child?
Homework Answers
Answer:
q^2=1/40,000 =2.5 x 10^-5
q=0.0000158
p+q=1
p=1-q=1-0.0000158=0.9999
Heterozygous genotype is a carrier= 2pq= 2 x 0.0000158 x 0.9999 =3.15 x 10^5
Probability of carrier couple having an affected baby in autosomal recessive disorder is ¼
One of the parent is confirmed carrier, other is 3.15 x 10^5 percent chance of being a carrier
Hence the total probability is = ¼ x 3.15 x 10^5= 0.865 x 10^5
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